The largest studies on this topic were conducted in the area of breast implants. The studies presented here are also valid for calf implants, as these are also made of silicone.
- June 1999; National Academy Institute of Medicine; Conclusion: Connective tissue disease, cancer, neurological disease and other systemic conditions are no more common in women who have silicone breast implants than in women without these implants.
- 1998; Sturrock R.D., FRCP, Independent Review Group (IRG); Conclusion: There is no association between silicone implants and connective tissue diseases …
- 1998; European Committee on Quality Assurance and Medical Devices in Plastic Surgery; Conclusion: Autoimmune or connective tissue diseases are not associated with breast implants. Furthermore, it is pointed out that current studies refute malignant degeneration caused by silicone-filled breast implants.
Pubmed:
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- Submuscular calf implants. – Kalixto MA, Vergara R. – Aesthetic Plast Surg. 2003 Mar-Apr;27(2):135-8 .
- Calf augmentation with new solid silicone implants. – Lemperle G, Kostka K. – Aesthetic Plast Surg. 1993 Summer;17(3):233-7 .
- Alloplastic implants for men. – Novack BH. – Clin Plast Surg. 1991 Oct;18(4):829-55. review .